Dr. Theoharides will present about inflammation occurring in the amygdala that is due to activation of mast cells. This inflammation is often associated with allergic reactions, but also present in the brain where they can be triggered by neuropeptides, stress and toxins leading to activation of microglia.
Dr. Theoharides is Professor of Pharmacology and Internal Medicine, as well as Director of Molecular Immunopharmacology and Drug Discovery, in the Department of Immunology at Tufts University School of Medicine.
He first showed that mast cells, known for causing allergic reactions, are critical for inflammation, especially in the brain, and are involved in a number of inflammatory conditions that worsen with stress such as allergies, asthma, autism spectrum disorder, eczema, fibromyalgia, interstitial cystitis/bladder pain syndrome, mast cell activation syndrome, migraines, multiple sclerosis, myalgic encephalomyelitis/chronic fatigue syndrome and psoriasis. Dr. Theoharides is also the Scientific Director of Algonot, LLC.
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