Leucovorin & Autism

Leucovorin (prescription-strength folinic acid) is a form of folate (vitamin B9) that can play an important role in supporting brain health, especially for individuals diagnosed with autism who have autoantibodies preventing folate from reaching the brain.  

This page brings together trusted information, expert insight, and family resources to help you learn more. 

Leucovorin for Autism

Learn About Leucovorin

• What is Leucovorin? How is it different from other forms of folate?

• Testing for folate autoantibodies and research dosing considerations.

• Why some individuals on the autism spectrum may respond positively.

• Practical considerations for families exploring this treatment.

The Science: Cerebral Folate Deficiency

Learn about Cerebral Folate Deficiency (CFD), a condition where there is a normal amount of folate in the blood but not enough folate reaching the brain. This can impact communication, behavior, and development. Discover how Leucovorin can help overcome this barrier and support healthy brain function. 

Read More About the Science Listen to the Interview

Listen: Expert Interview

Hear directly from Dr. Richard Frye, a leading researcher and clinician, as he explains: 

• What is Leucovorin

• How it may help individuals with autism

• What families should know before starting treatment

Learn In Person

Join us at the TACA National Autism Conference this October 10 -12 in Costa Mesa, CA to hear experts discuss Leucovorin, folate pathways, and other emerging treatments. Can’t attend in person? No problem, you can purchase all of the presentations through our Recorded Access ticket and get educated from the comfort of your home!  

Register for the TACA Conference

Get Support with TACA – Hope & Help for Autism Facebook Group

You don’t have to navigate this alone. Connect with other parents in the TACA – Hope & Help for Autism Facebook group, where trained staff and experienced families provide guidance and encouragement. 

Join TACA – Hope & Help for Autism

Attend Virtual Meetings

Participate in upcoming Zoom meetings (event details coming soon) to learn more, ask questions, and connect with other families exploring Leucovorin.

TACA Virtual Meetings

Parent Resources

• TACA Autism Workbook – Practical tools, checklists, and step-by-step guides for families. 

• Treatment & Therapy Articles – Explore evidence-based resources to better understand autism interventions. 

Healthy Babies: Prevention Matters

Planning for pregnancy or already expecting? Learn about strategies for a healthy pregnancy, including the role of folate and nutrition before and during pregnancy. 

Learn about Supporting a Healthy Pregnancy

Support Our Efforts

• Your gift helps TACA provide families with access to education, resources, and hope. 

Donate Today